Ca2+/calmodulin-dependent protein kinase II in heart failure
نویسندگان
چکیده
منابع مشابه
Calmodulin-dependent protein kinase II: linking heart failure and arrhythmias.
Understanding relationships between heart failure and arrhythmias, important causes of suffering and sudden death, remains an unmet goal for biomedical researchers and physicians. Evidence assembled over the past decade supports a view that activation of the multifunctional Ca(2+) and calmodulin-dependent protein kinase II (CaMKII) favors myocardial dysfunction and cell membrane electrical inst...
متن کاملCalcium/calmodulin-dependent protein kinase II contributes to cardiac arrhythmogenesis in heart failure.
BACKGROUND Transgenic (TG) Ca/calmodulin-dependent protein kinase II (CaMKII)delta(C) mice have heart failure and isoproterenol (ISO)-inducible arrhythmias. We hypothesized that CaMKII contributes to arrhythmias and underlying cellular events and that inhibition of CaMKII reduces cardiac arrhythmogenesis in vitro and in vivo. METHODS AND RESULTS Under baseline conditions, isolated cardiac myo...
متن کاملRole of Ca2+/calmodulin-dependent protein kinase II in cardiac hypertrophy and heart failure.
Ca2+/calmodulin-dependent protein kinase II (CaMKII), a critical transducer of Ca2+ signaling, is a multifunctional protein kinase which can phosphorylate a wide range of substrates and regulate numerous cellular functions. The delta isoforms of CaMKII predominate in the heart and two splice variants of CaMKIIdelta, deltaB and deltaC, have been demonstrated to be present in the adult mammalian ...
متن کاملReview Calmodulin-Dependent Protein Kinase II: Linking Heart Failure and Arrhythmias
Understanding relationships between heart failure and arrhythmias, important causes of suffering and sudden death, remains an unmet goal for biomedical researchers and physicians. Evidence assembled over the past decade supports a view that activation of the multifunctional Ca and calmodulin-dependent protein kinase II (CaMKII) favors myocardial dysfunction and cell membrane electrical instabil...
متن کاملCalcium/Calmodulin-Dependent Protein Kinase II Activity Persists During Chronic β-Adrenoceptor Blockade in Experimental and Human Heart Failure.
BACKGROUND Considerable evidence suggests that calcium/calmodulin-dependent protein kinase II (CaMKII) overactivity plays a crucial role in the pathophysiology of heart failure (HF), a condition characterized by excessive β-adrenoceptor (β-AR) stimulation. Recent studies indicate a significant cross talk between β-AR signaling and CaMKII activation presenting CaMKII as a possible downstream med...
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ژورنال
عنوان ژورنال: Drug Discovery Today: Disease Mechanisms
سال: 2010
ISSN: 1740-6765
DOI: 10.1016/j.ddmec.2010.07.005